Detectives intercepted the 63-year-old man in his Ford utility at the Ord River Roadhouse, and officers searched his vehicle alleging to have uncovered a large quantity of cannabis.
The street value of the haul is estimated at $400,000.
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The man will appear in Kununurra Magistrate's Court this morning, charged with possession of a prohibited drug with intent to sell or supply.
Police would not confirm if this latest drug find is related to a number of recent arrests of Gypsy Joker Motorcycle Gang members who had allegedly been using truck drivers to bring large quantities of cannabis into WA from South Australia.
On April 7, three South Australian truck drivers and a 41-year-old Kalgoorlie man with links to the bikie gang have were charged over the seizure of 29.1 kilograms of cannabis, with a street value of close to $1.5 million.
On April 30, two WA men were charged over a 20 kilogram cannabis haul allegedly uncovered in the vehicle of one of the men, estimated to be worth about $500,000.
In addition to this, police also seized about 29 kilograms of South Australian cannabis in WA during March.